Thursday, May 11, 2023

AAI Council Meeting

By invitation only

Registration, AAI Member Lounge, and Information Desk Open

• The Registration Desk is to just your right as you enter Exhibit Hall D.
• The AAI Member Lounge is in the front left corner of Exhibit Hall D.
• The Information Desk is just to your left as you enter Exhibit Hall D.

Speaker Ready Room Open

All speakers are required to go to the Speaker Ready Room at least 4 hours prior to the start of their session to ensure their presentation is properly uploaded and displays correctly. For details, visit the IMMUNOLOGY2023™ Podium Presentation Guidelines page.

AAI Staff Office Open

AAI staff will be available at the AAI Staff Office to assist attendees during the meeting.

KiddieCorp Child Care Room Open

Child care will be provided by KiddieCorp at no cost to attendees. For details, visit the IMMUNOLOGY2023™ Child Care page.

AAI Membership Committee Meeting

By invitation only

AAI Committee on Public Affairs Meeting

By invitation only

1. Back to School: A Review of Four Fast-Moving Fields

Sponsored by the AAI Program Committee

Chairs

• Cathryn R. Nagler, Univ. of Chicago, AAI Program Committee Chair
• Chandrashekhar Pasare, Cincinnati Children’s Hosp. Med. Ctr.

Speakers

• Judith A. James, Oklahoma Med. Res. Fndn., Cross-reactive B cells
• Chandrashekhar Pasare, Cincinnati Children’s Hosp. Med. Ctr., Mechanisms of microbial and non-microbial (sterile) innate inflammation
• Timothy E. O’Sullivan, Univ. of California, Los Angeles, CRISPR-Cas9 tools and technology in immunity
• Golnaz Vahedi, Univ. of Pennsylvania Perelman Sch. of Med., Advances in single-cell analysis

2. Block Symposium

B Cell and T Helper Cell Responses During Viral Infections

Chairs

• Pooja Jain, Drexel Univ. Col. of Med.
• Tara Strutt, Univ. of Central Florida

Speakers

• Christopher A. Risley, Univ. of Alabama at Birmingham, T-bet controls the maintenance and differentiation potential of flu-induced effector memory B cells
• Arien Schiepers, Rockefeller Univ., Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization
• Patrick Ilunga Mpingabo, NIAID, NIH, Detection of envelope-dimer epitope-like broadly protective antibodies in dengue-immune children in the Philippines following vaccination and natural infection
• Claire E. Otero, Weill Cornell Med., Rhesus macaque cytomegalovirus deploys viral Fc γ receptors to evade antibody-mediated cellular immunity
• Mirela Kuka, Univ. Vita Salute San Raffaele, Italy, Interferon gamma supresses T follicular helper cell and antibody responses upon viral infection
• Tanushree Dangi, Feinberg Sch. of Med., Northwestern Univ., Pre-existing immunity modulates responses to mRNA boosters
• Valeria Flores Malavet, Univ. of Central Florida, Memory CD4 T cell recall following Influenza A Virus infection is unaltered by the pregnancy environment
• Tineke Cantaert, Inst. Pasteur du Cambodge, Cambodia, Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites

3. Block Symposium

Epithelial-Associated Immune Responses

Chairs

• Luisa Cervantes-Barragan, Emory Univ.
• Theresa Alenghat, Cincinnati Children's Hosp. Med. Ctr.

Speakers

• Dan Corral, NIAID, NIH, Maternal immune regulation of lactogenesis
• Ellen Merrick Schill, Washington Univ. in St. Louis Sch. of Med., early life antibiotic exposures inhibits postnatal enteric nervous system maturation and alters neonatal neuroimmune interactions
• Emily M. Eshleman, Cincinnati Children's Hosp. Med. Ctr., Microbiota dampen type 2 immunity by epigenetically restricting tuft cell differentiation
• Chuan Wu, NCI, NIH, Lipid sensing by gut CD1d calibrates peripheral serotonin release
• Ankit Malik, Univ. of Chicago, Compartmentalized antigen presentation and inflammasome activation between epithelial cells and macrophages orchestrates gut immunity
• Deepika Sharma, Univ. of Chicago, Neuronal cells co-ordinate myeloid-epithelial cell interaction to regulate intestinal inflammation
• Bibiana E. Barrios, Washington Univ. in St. Louis Sch. of Med., MHCII expression by intestinal goblet cells in immune homeostasis
• Natasha B. Golovchenko, Rutgers New Jersey Med. Sch., γδ intraepithelial lymphocyte number and motility precede the onset of Crohn's disease-like ileitis.

4. Block Symposium

Immune Responses to Microbial, Parasitic, and Fungal Infections

Chairs

• Tiffany Weinkopff, Univ. of Arkansas Sch. of Med.
• Olanrewaju Morenikeji, Univ. of Pittsburgh

Speakers

• Sumanta Kumar Naik, Washington Univ. in St Louis Sch. of Med., Determining the mechanistic basis for Irgm1 mediated control of Mycobacterium tuberculosis infection
• Subhajit Roy, Univ. of California, Irvine, Host gut-resistome and gut-immune axes are the key to non-cholera Vibrio infection severity in aging and heat stress
• Camila Farias Amorim, Univ. of Pennsylvania, Staphylococcus aureus promotes increase IL-1 mediated immunopathology and delayed healing in cutaneous leishmaniasis
• Miguel Antonio Bernabe Mercado, Univ. of Arkansas for Med. Sci., Transcription factor Bhlhe40 plays a protective role during intravaginal Chlamydia muridarum infection in mice
• Lee Ann Garrett-Sinha, State Univ. of New York at Buffalo, Dendritic epidermal T cells (DETC) are not required for control of skin Staph infections
• Purevdorj B. Olkhanud, NCI, NIH, Bi-directional crosstalk between gut microbiota and NKT cells
• Lucy Fry, Univ. of Arkansas for Med. Sci., Distinct lymphatic remodeling is associated with healing and non-healing murine cutaneous leishmaniasis
• Lila T. Witt, Mayo Clin., γδ T cells contribute to immunopathology during neonatal sepsis in an age-dependent manner

5. Block Symposium

Immune Therapy in Cancer

Chairs

• Michael A. Farrar, Univ. of Minnesota Med. Sch.
• Tyler J. Curier, Dartmouth Col.

Speakers

• Xinyi Tu, Mayo Clin., A new PD-L1 antibody H1A causse PD-L1 degradation and sensitizes cancer cells for cytotoxic therapy
• Ling Li, Erasmus Univ. Med. Ctr., Netherlands, ITK inhibition improves the response to immune checkpoint blockade in solid tumors
• Hrishi Venkatesh, Univ. of Minnesota, B cell leukemia elicits a suppressive Tr1-like CD4 T cell response that can be reversed with anti-PDL1-blockade
• Tina Kwok, Mayo Clin., The effects of αPD-1 and αPD-L1 therapy on macrophage remodeling within the solid tumor microenvironment
• Michael Walsh, Massachusetts Gen. Hosp., IL-21 or synthetic IL-2 treatment drives T cell IFNγ production or expansion, respectively, during adoptive cell therapy of melanoma
• Vivien Ileana Maltez, NIAID, NIH, Hijacking suppression: anti-CD40 converts regulatory T cells Into type I effectors
• Clare Murray, The Univ. of Texas Hlth. Sci. Ctr. at San Antonio, Pharmacologic tumor PDL1 depletion as a novel approach to overcome treatment resistance
• Miho Tanaka, Univ. of California, San Francisco, An immunosuppressive tumor population drives immunotherapy resistance of heterogeneous tumors
• Christina Kratzmeier, Univ. of Maryland Sch. of Med., Unique immunoregulation of lung cancer by CD8+ T cells

6. Block Symposium

Innate Immune Responses and Host Defense

Speakers

• Christine Youn, Johns Hopkins Univ. Sch. of Med., TNF receptors orchestrate differential neutrophil responses critical to immunity against Staphylococcus aureus skin infection
• Kimberly Oliva, Univ. of Georgia, Inflammation-induced development and migration of a novel monocyte-like dendritic cell population that regulates antiviral CD8 T cell immunity
• Skyler V. Hendrix, Washington Univ. in St Louis Sch. of Med., Investigating the role of BHLHE40 in host responses to Mycobacterium tuberculosis infection and myeloid cell development
• Eden Faneuff, Vanderbilt Univ. Med. Ctr., Myeloid PTEN inhibits innate host defense during methicillin-resistant Staphylococcus aureus-induced sepsis
• Helen Eva Adams Rich, Univ. of Michigan, Epithelial TLR9 upregulation by respiratory viruses impairs pulmonary antibacterial immunity
• Roshan Ghimire, Oklahoma State Univ., Differential role of TLR7 signaling in SARS-CoV-2-induced antiviral and inflammatory responses
• Lindsey D. Hughes, Yale Univ. Sch. of Med., Effector response to necroptotic cell death: an ensemble of immune and stromal cells
• Aaron P. Esser-Kahn, Univ. of Chicago, Identifying and targeting a subpopulation of dendritic cells with enhanced activation of adaptive responses—identifying first responders

7. Block Symposium

Innate Sensing and Disease

Chairs

• Justin E. Wilson, Univ. of Arizona Cancer Ctr.
• Zizhen Kang, Univ. of Iowa

Speakers

• Thierry Gauthier, NIDCR, NIH, TGF-β promotes glycolysis through PFKL in activated macrophages and exacerbates sepsis by disrupting blood coagulation
• Karla Yvonne García-Martínez, Cornell Univ., A role for stimulator of interferon genes in toll-like receptor 8 signaling
• Stefanie M. Bader, Walter and Eliza Hall Inst. of Med. Res., Australia, TNF mediates inflammation and cytokine release through Caspase-8 during SARS-CoV-2 infection in vivo
• Alex J. Suptela, Univ. of North Carolina at Charlott, Human microglial responses to DNA damage are mediated by the cytosolic sensor cGAS
• Yuhang Wang, Univ. of Iowa, An animal model for autoinflammation with infantile enterocolitis
• Andrew G. Harrison, Univ. of Connecticut Hlth. Ctr., The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity
• Justin E. Wilson, Univ. of Arizona, AIM2 promotes epithelial tuft cell development during intestinal type 2 immune responses
• Abigail Morales, Hunter College, DNA-PKcs regulates transcriptional networks in activated macrophages

8. Block Symposium

Metabolic and Gut Microbiota: Effects on Autoimmunity

Chairs

• Rahman Ziaur, Penn State Univ. Col. of Med.
• Reiko Horai, NEI, NIH

Speakers

• Kristen N. Bricker, Penn State Univ. Col. of Med., miR-21 promotes B cell autoreactivity, inflammatory signaling, and metabolism in TLR7-driven systemic autoimmunity
• Niyati Jhaveri, Akoya Biosciences, Inc., Single-cell spatial phenotyping of immune and metabolic landscapes in systemic lupus erythematosus
• Tarun Pant, Med. Col. of Wisconsin, Lnk/Sh2b3 modulates bioenergetic metabolism of activated CD8 T cells and control the development of Type 1 Diabetes
• Angela M. Thornton, NIAID,NIH, Acquired lipodystrophy is mediated by a Treg cpecific deletion of helios
• Vidyanath Chaudhary, Hosp. for Special Surgery, Regulation of plasmacytoid dendritic cells by ER stress-mediated metabolic responses
• Jing Ma, Univ. of Louisville, Intestinal lamina propria stromal cells function as the target of androgens and microbiota metabolites for the prevention of lupus
• Stephanie R. Peterson, Univ. of Iowa, Gut microbiome-derived isoflavone metabolites may ameliorate experimental autoimmune encephalomyelitis (EAE) through estrogen receptor signaling in CD8 T-cells
• Amy Zhang, NEI, NIH, Human gut commensals support development of ocular autoimmunity in retina-specific T cell receptor transgenic mice

9. Block Symposium

Myeloid Cells in Cancer Hosts I

Chairs

• Melanie R. Rutkowski, Univ. of Virginia
• Tracy McGaha, Univ. Hlth. Network

Speakers

• Mitchell Thomas McGinty, Univ. of Virginia, Absence of Toll-like receptor 5 confers survival in mice bearing ovarian tumors treated with anti-PD-L1
• Anthony Michael Cannon, Indiana Univ. Sch. of Med., IL-9 responsive macrophages utilize Arginase 1 to enhance lung tumor growth
• Devanshi A. Nayak, Univ. of Pittsburgh Sch. of Med., Elucidating the role of heat shock protein receptor CD91 on antigen presenting cells during cancer immunosurveillance
• Sara Lamorte, Univ. Hlth. Network, Canada, Medullary sinus macrophages limit cancer therapy efficacy by an efferocytosis-induced IL-33/ST2 axis in the tumor-draining lymph node
• Olivia J. Cheng, Univ. of Utah Sch. of Med., MAIT cell-mediated inhibition of colorectal tumor growth is associated with increase in IL-5 and accumulation of eosinophils in the tumor microenvironment
• Hyun-Jin Kim, Korea Adv. Inst. of Sci. and Technol., South Korea, Monocyte-derived CD169⁺ macrophages advance the antitumor immunity against glioblastoma multiforme

10. Block Symposium

Vaccination and Vaccine-induced Responses against Pathogens at Target Sites

Chairs

• Mangala Rao, Walter Reed Army Inst. of Res.
• Todd Bradley, Univ. of Kansas Med. Ctr.

Speakers

• Dennis Lapuente, Univ. Hosp. Erlangen, Germany, Adenoviral vector vaccines are effective mucosal booster modalities to elevate systemic and establish mucosal immunity against SARS-CoV-2
• Qin Xu, NIAID, NIH, mRNA vaccination induces persistent pharyngeal mucosal B cell responses to SARS-CoV-2 in children
• Wenxia Jiang, Indiana Univ. Sch. of Med., Boosting location of COVID-19 mRNA vaccine regulates the germinal center reaction
• Devdoot Majumdar, Univ. of Vermont, Understanding mechanisms of adjuvancy in muscle by mRNA/lipid nanoparticles
• Eric S. Geanes, Children's Mercy Kansas City, Blocking respiratory syncytial virus infection utilizing decoy ICAM-1 receptor proteins
• Chunhong Dong, Georgia State Univ., Particulate characteristics of engineered nanoparticle vaccines modulate vaccine immunogenicity in an intranasal route
• Allison N. Bucsan, NIAID, NIH, Visualizing the early immune response to Mycobacterium tuberculosis infection in macaques immunized with intravenous BCG

New Member Reception

Sponsored by the AAI Membership Committee
Generously supported by BD Biosciences

Are you a new AAI Regular, Associate, or Postdoctoral Fellow member? Please join us for a special reception welcoming you to AAI and perhaps your very first AAI annual meeting! AAI President Mark Davis will say a few words, and you will have the opportunity to meet and mingle with AAI Council members, AAI staff, members of the Membership Committee, and other fellow new members!

(Light refreshments will be served. Badge and invitation are required.)

11. President’s Address

Generously supported by GSK

Presentation of AAI Lifetime Achievement Award and Acknowledgment of Distinguished Fellows of AAI Class of 2023

11. AAI Lifetime Achievement Award Presentation

AAI President Mark M. Davis will introduce the awardee and present the award prior to the start of the President's Address.

Chair

• Mark M. Davis, HHMI, Stanford Univ. Sch. of Med., AAI President

Award Recipient

The AAI Lifetime Achievement Award is the highest honor bestowed by the AAI Council upon an AAI member. This award recognizes a deserving member for a career of scientific achievement and for contributions to AAI and fellow immunologists.

11. Distinguished Fellows of AAI Class of 2023 Acknowledgment

AAI President Mark M. Davis will acknowledge the honorees prior to the start of the President's Address.

Chair

• Mark M. Davis, HHMI, Stanford Univ. Sch. of Med., AAI President

The Distinguished Fellows of AAI annually recognizes members for distinguished careers and outstanding scientific contributions as well as their service to AAI and the immunology community. It honors active, long-term members (25 or more years) who have demonstrated one or more of the following: excellence in research accomplishment in the field of immunology; exceptional leadership to the immunology community in academia, foundations, nonprofits, industry, or government at a national or international level; notable distinction as an educator.

Meet the Distinguished Fellows of AAI Class of 2023.

IMMUNOLOGY2023™ Opening Night Welcome Reception

Following the President’s Address, join the Opening Night Welcome Reception in the convention center. Connect with friends, make new acquaintances, plan your week, and enjoy beautiful views of our nation’s capital city. One complimentary drink ticket is included and attached to your name badge.

(Attendees must be 21 years of age or older. Badge is required.)

AAI Public Policy Fellows Dinner

Sponsored by the AAI Committee on Public Affairs

By invitation only