Friday, May 12, 2023     3:45 PM – 5:45 PM ET     Room 204ABC

Block Symposium

T Cells in Cancer: From Memory to Exhaustion

Chairs

• Hazem Ghoneim, Ohio State Univ. Wexner Med. Ctr.
• Zihai Li , Ohio State Univ. Comprehensive Cancer Ctr.

Speakers

• Delaney E. Ramirez, Geisel Sch. of Med., Dartmouth Col., Temporal requirements for TGF-β and IL-7 in generating resident memory T cell responses to melanoma
• Sierra A. Kleist, Geisel Sch. of Med., Dartmouth Col., Investigating the source of viral-specific memory T cells in glioblastoma
• Anwesha Kar, Indian Inst. of Chemical Bio., India, CD38-cADPR axis mediated chronic Ca²⁺ signaling promotes the differentiation of TCF1^lo terminal exhausted CD8⁺ T cells in tumor
• Tong Xiao, James Comprehensive Cancer Ctr., Ohio State Univ., Novel mechanisms of androgen receptor-centered transcriptional regulatory network in regulating CD8⁺ T cell exhaustion and sex bias in cancer
• Xin Lan, St. Jude Children's Res. Hosp., Exhausted CD8 T cell progenitors are sustained with TCR engagement during anti-tumor responses
• Hannah Dada, NCI, NIH, Effect of mechanical cues on T cell killing of cancer cells
• Amir Yousif, Ohio State Univ. Col. of Med., Targeting epigenetic crosstalk that restrains the responses of exhausted T cells to immune checkpoint blockade therapy
• Emilia Rae Dellacecca, Mayo Clin., DUSP2 functions as a negative regulator of cytotoxic T cell responses in cancer immunotherapy